CALY-002 the lead program of Calypso Biotech, is a best-in-class humanized monoclonal antibody inhibiting Interleukin-15 (IL-15). IL-15 is a cytokine mainly expressed by monocytes, dendritic cells and epithelial cells. IL-15 plays multiple roles in the immune system by controlling the homeostasis and activation of T, B, NK and tissue resident memory T cells. CALY-002 is well positioned as paradigm-changing treatment for several gastrointestinal indications with currently no approved treatment, as well as other large immune pathologies.